Hippuric acid synthesis in the rat

The Role of the Liver in Hippuric Acid Synthesis.

Studies in the Synthesis of Hippuric Acid in the Animal Organism. Ii. the Synthesis and Rate of Elimination of Hippuric Acid after Benzoate

The question of the extent of the ability of the human organism to detoxicate benzoic acid by conjugation with glycocoll and elimination as hippuric acid in the urine has frequently been raised. Lewinsk? observed in the urine of men to whom 12 to 20 grams of benzoic acid had been given in small doses during t,he course of twelve hours, neither free benzoic acid nor benzoyl glycuronates. With la...

The Site of the Synthesis of Hippuric Acid and Phenylaceturic Acid in the Dog*

At present the view is commonly accepted that hippuric acid is produced chiefly by the kidney in most animals and exclusively by that organ in the dog. This conclusion is based largely on the well known work of Bunge and Schmiedeberg (1) who were able to dem0nstrat.e that hippuric acid was formed when blood containing benzoic acid and glycine was perfused through dog kidney. Furthermore, they f...

Studies of Liver Function. Benzoate Administration and Hippuric Acid Synthesis

Much work has been done in an effort to understand the complex function of the liver and considerable information of value has been obtained. It is fair to say, however, that the estimation of functional capacity of the liver cannot as yet be made with any convincing accuracy. We have reason to believe that the liver has a very large factor of safety-that it can tolerate an extensive injury and...

Studies on the Synthesis of Hippuric Acid in the Animal Organism

The source of the glycocoll made available for detoxication after the ingestion of benzoic acid or its salts is not known. The possibility that hippuric acid is formed from the glycocoll secreted as glycocholic acid in the bile either in the intestine or in the circulatory system has been suggested. Such a theory would ascribe to the bile an important function. Little experimental evidence in s...